Interdisciplinary approaches Archives | Page 123 of 190

AI and AFM deliver real-time macrophage phenotyping

Macrophages drive immune responses, including inflammation, tissue repair, and tumour growth. Identifying their polarisation states is key for diagnosis and immunotherapy, but current methods, such as RNA sequencing and flow cytometry, are expensive, slow, and unsuitable for real-time use.

Atomic force microscopy (AFM) has emerged as a powerful tool for decoding mechanobiological signatures of cells. Combined with AI, AFM data can be rapidly analysed, but macrophage phenotyping has been relatively underexplored using this approach.

Researchers led by Prof Li Yang at the Shenzhen Institutes of Advanced Technology have now developed a label-free, non-invasive method combining AFM with deep learning. The system accurately profiles human macrophage mechanophenotypes and identifies polarisation states in real-time.

The AI model was trained on well-characterised macrophage subtypes and validated using flow cytometry. Results showed that pseudovirus stimulation mainly produced M1 macrophages, with smaller populations of M2 and mixed phenotypes, closely matching the model’s predictions.

The study, published in Small Methods, offers a promising diagnostic tool that could be extended beyond macrophages to other cell types. It could support new approaches in cancer, fibrosis, and infectious disease diagnostics based on mechanophenotypes.

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NotebookLM turns notes into flashcards podcasts and quizzes

Google’s learning-focused AI tool NotebookLM has gained a major update, making studying and teaching more interactive.

Instead of offering only static summaries, it now generates flashcards that condense key information into easy-to-remember notes, helping users recall knowledge more effectively.

Reports can also be transformed into quizzes with customisable topics and difficulty, which can then be shared with friends or colleagues through a simple link.

The update extends to audio learning, where NotebookLM’s podcast-style Audio Overviews are evolving with new formats. Instead of a single style, users can now create Brief, Debate, or Critique episodes, giving greater flexibility in how material is explained or discussed.

Google is also strengthening its teaching tools. A new Blog Post format offers contextual suggestions such as strategy papers or explainers, while the ability to create custom report formats allows users to design study resources tailored to their needs.

The most significant addition, however, is the Learning Guide. Acting like a personal tutor, it promotes deeper understanding by asking open-ended questions, breaking problems into smaller steps, and adapting explanations to suit each learner.

With these features, NotebookLM is moving closer to becoming a comprehensive learning assistant, offering a mix of interactive study aids and adaptable teaching methods that go beyond simple note-taking.

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Photonic chips open the path to sustainable AI by training with light

A team of international researchers has shown how training neural networks directly with light on photonic chips could make AI faster and more sustainable.

A breakthrough study, published in Nature, involved collaboration between the Politecnico di Milano, EPFL Lausanne, Stanford University, the University of Cambridge, and the Max Planck Institute.

The research highlights how physical neural networks, which use analogue circuits that exploit the laws of physics, can process information in new ways.

Photonic chips developed at the Politecnico di Milano perform mathematical operations such as addition and multiplication through light interference on silicon microchips only a few millimetres in size.

By eliminating the need to digitise information, these chips dramatically cut both processing time and energy use. Researchers have also pioneered an ‘in-situ’ training technique that enables photonic neural networks to learn tasks entirely through light signals, instead of relying on digital models.

The result is a training process that is faster, more efficient and more robust.

Such advances could lead to more powerful AI models capable of running directly on devices instead of being dependent on energy-hungry data centres.

An approach that paves the way for technologies such as autonomous vehicles, portable intelligent sensors and real-time data processing systems that are both greener and quicker.

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Canadian news publishers clash with OpenAI in landmark copyright case

OpenAI is set to argue in an Ontario court that a copyright lawsuit by Canadian news publishers should be heard in the United States. The case, the first of its kind in Canada, alleges that OpenAI scraped Canadian news content to train ChatGPT without permission or payment.

The coalition of publishers, including CBC/Radio-Canada, The Globe and Mail, and Postmedia, says the material was created and hosted in Ontario, making the province the proper venue. They warn that accepting OpenAI’s stance would undermine Canadian sovereignty in the digital economy.

OpenAI, however, says the training of its models and web crawling occurred outside Canada and that the Copyright Act cannot apply extraterritorially. It argues the publishers are politicising the case by framing it as a matter of sovereignty rather than jurisdiction.

The dispute reflects a broader global clash over how generative AI systems use copyrighted works. US courts are already handling several similar cases, though no clear precedent has been established on whether such use qualifies as fair use.

Publishers argue Canadian courts must decide the matter domestically, while OpenAI insists it belongs in US courts. The outcome could shape how copyright laws apply to AI training and digital content across borders.

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Ransomware 3.0 raises alarm over AI-generated cyber threats

Researchers at NYU’s Tandon School of Engineering have demonstrated how large language models can be utilised to execute ransomware campaigns autonomously. Their prototype, dubbed Ransomware 3.0, simulated every stage of an attack, from intrusion to the generation of a ransom note.

The system briefly raised an alarm after cybersecurity firm ESET discovered its files on VirusTotal, mistakenly identifying them as live malware. The proof-of-concept was designed only for controlled laboratory use and posed no risk outside testing environments.

Instead of pre-written code, the prototype embedded text instructions that triggered AI models to generate tailored attack scripts. Each execution created unique code, evading traditional detection methods and running across Windows, Linux, and Raspberry Pi systems.

The researchers found that the system identified up to 96% of sensitive files and could generate personalised extortion notes, raising psychological pressure on victims. With costs as low as $0.70 per attack using commercial AI services, such methods could lower barriers for criminals.

The team stressed that the work was conducted ethically and aims to help defenders prepare countermeasures. They recommend monitoring file access patterns, limiting outbound AI connections, and developing defences against AI-generated attack behaviours.

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Pressure mounts as Apple prepares AI search push with Google ties

Apple’s struggles in the AI race have been hard to miss. Its Apple Intelligence launch was disappointing, and its reliance on ChatGPT appeared to be a concession to rivals.

Bloomberg’s Mark Gurman now reports that Apple plans to introduce its AI-powered web search tool in spring 2026. The move would position it against OpenAI and Perplexity, while renewing pressure on Google.

The speculation comes after news that Google may integrate its Gemini AI into Apple devices. During an antitrust trial in April, Google CEO Sundar Pichai confirmed plans to roll out updates later this year.

According to Gurman, Apple and Google finalised an agreement for Apple to test a Google-developed AI model to boost its voice assistant. The partnership reflects Apple’s mixed strategy of dependence and rivalry with Google.

With a strong record for accurate Apple forecasts, Gurman suggests the company hopes the move will narrow its competitive gap. Whether it can outpace Google, especially given Pixel’s strong AI features, remains an open question.

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Teens turn to AI chatbots for support, raising mental health concerns

Mental health experts in Iowa have warned that teenagers are increasingly turning to AI chatbots instead of seeking human connection, raising concerns about misinformation and harmful advice.

The issue comes into focus on National Suicide Prevention Day, shortly after a lawsuit against ChatGPT was filed over a teenager’s suicide.

Jessica Bartz, a therapy supervisor at Vera French Duck Creek, said young people are at a vulnerable stage of identity formation while family communication often breaks down.

She noted that some teens use chatbot tools like ChatGPT, Genius and Copilot to self-diagnose, which can reinforce inaccurate or damaging ideas.

‘Sometimes AI can validate the wrong things,’ Bartz said, stressing that algorithms only reflect the limited information users provide.

Without human guidance, young people risk misinterpreting results and worsening their struggles.

Experts recommend that parents and trusted adults engage directly with teenagers, offering empathy and open communication instead of leaving them dependent on technology.

Bartz emphasised that nothing can replace a caring person noticing warning signs and intervening to protect a child’s well-being.

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AI in weather forecasting takes centre stage in Abu Dhabi

Abu Dhabi hosted a Weather Summit that explored how AI could transform forecasting and support operations, such as cloud seeding. Experts emphasised that AI enhances analysis but must complement, rather than replace, human judgement.

Discussions focused on Earth-system forecasting using satellite datasets, IoT devices, and geospatial systems. Quality, interoperability, and equitable access to weather services were highlighted as pressing priorities.

Speakers raised questions about public and private sector incentives’ reliability, transparency, and influence on AI. Collaboration across sectors was crucial to strengthening trust and global cooperation in meteorology.

WMO President Dr Abdulla Al Mandous said forecasting has evolved from traditional observation to supercomputing and AI. He argued that integrating models with AI could deliver more precise local forecasts for agriculture, aviation, and disaster management.

The summit brought together leaders from UN bodies, research institutions, and tech firms, including Google, Microsoft, and NVIDIA. Attendees highlighted the need to bridge data gaps, particularly in developing regions, to confront rising climate challenges.

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International search widens for ransomware fugitive on EU Most Wanted

A Ukrainian cybercrime suspect has been added to the EU’s Most Wanted list for his role in the 2019 LockerGoga ransomware attack against a major Norwegian aluminium company and other global incidents.

The fugitive is considered a high-value target and is wanted by multiple countries. The US Department of Justice has offered up to USD 10 million for information leading to the arrest.

Europol stated that the identification of the suspect followed a lengthy, multinational investigation supported by Eurojust, with damages from the network estimated to be in the billions. Several members of the group have already been detained in Ukraine.

Investigators have mapped the network’s operations, tracing its hierarchy from malware developers and intrusion experts to money launderers who processed illicit proceeds. The wanted man is accused of directly deploying LockerGoga ransomware.

Europol has urged the public to visit the EU Most Wanted website and share information that could assist in locating the fugitive. The suspect’s profile is now live on the platform.

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Momenta set for first European robotaxi rollout with Uber in Germany

Uber and Chinese startup Momenta will begin robotaxi t esting in Munich in 2026, marking their first public deployment in continental Europe. The trials will start with human safety operators, with plans to expand across additional European cities.

Founded in 2016, Momenta is one of China’s leading autonomous vehicle companies, having tested self-driving cars since 2018. The company is already collaborating with automakers such as Mercedes-Benz and BMW to integrate advanced driver assistance systems.

Uber is broadening its global AV network, which already spans 20 partners across mobility, delivery, and freight. In the U S, Waymo robotaxis operate via Uber’s app, while international partnerships include WeRide in the Gulf and Wayve in London.

Competition in Europe is intensifying. Baidu from China and Lyft plan to roll out robotaxis in Germany and the UK next year, while Uber has chosen Munich, Germany, as its engineering base and a strong automotive ecosystem.

German regulators must still certify Momenta’s technology and approve geo-fenced operating areas. If successful, Munich will become Momenta’s first European launchpad, building on its Shanghai robotaxi service and global ADAS deployment.

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