Thyroid cancer, the most common endocrine malignancy, poses challenges for surgeons trying to remove tumours while preserving healthy tissue.
Fine-needle aspiration and pathology are accurate but slow, providing no real-time guidance and sometimes causing unnecessary or incomplete surgeries. Dynamic Optical Contrast Imaging (DOCI) uses cells’ natural light to quickly distinguish healthy tissue from cancer.
The technique captures 23 optical channels from freshly excised tissue, creating detailed spectral maps without dyes or contrast agents. These optical signatures allow for rapid, label-free tissue analysis.
Researchers at Duke University and UCLA combined DOCI with AI to improve accuracy in classification and localisation. A two-stage machine-learning approach first categorised tissue as healthy or cancerous, including common and aggressive thyroid cancer subtypes.
Deep-learning models then produced tumour probability maps, pinpointing cancerous regions with minimal false positives.
Although initial studies focused on post-excision tissue, the technology could soon offer surgeons real-time guidance in the operating room. By combining optical imaging with AI, DOCI may reduce unnecessary surgery, preserve healthy tissue, and improve outcomes for thyroid cancer patients.
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