Scaling a cell ‘language’ model yields new immunotherapy leads
A 27B ‘cell language’ model generated a cancer hypothesis later confirmed, pointing to AI-guided routes for immunotherapy.
Yale University and Google unveiled Cell2Sentence-Scale 27B, a 27-billion-parameter model built on Gemma to decode the ‘language’ of cells. The system generated a novel hypothesis about cancer cell behaviour, and CEO Sundar Pichai called it ‘an exciting milestone’ for AI in science.
The work targets a core problem in immunotherapy: many tumours are ‘cold’ and evade immune detection. Making them visible requires boosting antigen presentation. C2S-Scale sought a ‘conditional amplifier’ drug that boosts signals only in immune-context-positive settings.
Smaller models lacked the reasoning to solve the problem, but scaling to 27B parameters unlocked the capability. The team then simulated 4,000 drugs across patient samples. The model flagged context-specific boosters of antigen presentation, with 10–30% already known and the rest entirely novel.
Researchers emphasise that conditional amplification aims to raise immune signals only where key proteins are present. That could reduce off-target effects and make ‘cold’ tumours discoverable. The result hints at AI-guided routes to more precise cancer therapies.
Google has released C2S-Scale 27B on GitHub and Hugging Face for the community to explore. The approach blends large-scale language modelling with cell biology, signalling a new toolkit for hypothesis generation, drug prioritisation, and patient-relevant testing.
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